- The antacid should not be absorbable or cause systemic alkalosis
- The antacid should not be a laxative or causes constipation
- The antacid should exert its effect rapidly and over a long period of time
- The antacid should buffer in the pH 4-6 range
- The reaction of the antacid with gastric HCl acid should not cause a large evolution of gas
- The antacid should probably inhibit pepsin
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